Spis publikacji od utworzenia Zakładu Fizykochemicznej Analizy Leku

2023

• Stary, D.; Nepovimova, E.; Kuca, K.; Bajda, M.; Searching for new mTOR kinase inhibitors: analysis of binding sites and validation of docking protocols, Biol. Drug Des. 2023, 101: 103–119
• Czarnecka, K.; Girek, M.; Kręcisz, P.; Skibiński, R.; Łątka, K.; Jończyk, J.; Bajda, M.; Szymczyk, P.; Galita, G.; Kabziński, J.; Majsterek, I.; Espargaró, A.; Sabate, R.; Szymański, P.; New cyclopentaquinoline and 3,5-dichlorobenzoic acid hybrids with neuroprotection against oxidative stress for the treatment of Alzheimer’s disease, Enzym. Inhib. Med. Chem. 2023, 38(1), 2158822
• Godyń, J.; Zaręba, P.; Stary, D.; Kaleta, M.; Kuder, K.J.; Latacz, G.; Mogilski, S.; Reiner-Link, D.; Frank, A.; Doroz-Płonka, A.; Olejarz-Maciej, A.; Sudoł-Tałaj, S.; Nolte, T.; Handzlik, J.; Stark, H.; Więckowska, A.; Malawska, B.; Kieć-Kononowicz, K.; Łażewska, D.; Bajda, M.; Benzophenone derivatives with histamine H₃ receptor affinity and cholinesterase inhibitory potency as multitarget-directed ligands for possible therapy of Alzheimer’s disease, Molecules 2023, 28: 238
• Stary, D.; Bajda, M.; Taurine and creatine transporters as potential drug targets in cancer therapy. J. Mol. Sci. 2023, 24(4): 3788

2022

• Stary, D.; Kukułowicz, J.; Góral, I.; Baltrukevich, H.; Barbasevich, M.; Godyń, J.; Bajda, M.; Multilevel virtual screening approach for discovery of thymidine phosphorylase inhibitors as potential anticancer agents, Mol. Struct. 2022, 1249: 131648
• Łątka, K.; Bajda, M.; Analysis of binding determinants for different classes of competitive and noncompetitive inhibitors of glycine transporters, J. Mol. Sci. 2022, 23: 8050
• Chałupnik, P.; Vialko, A.; Pickering, D.S.; Hinkkanen, M.; Donbosco, S.; Moller, T.C.; Jensen, A.A.; Nielsen, B.; Bay, Y.; Kristensen, A.S.; Johansen, T.N.; Łątka, K.; Bajda, M.; Szymańska, E.; Discovery of the first highly selective antagonist of the GluK3 kainate receptor subtype, J. Mol. Sci. 2022, 23: 8050
• Łątka, K.; Bajda, M.; Analysis of different binding modes for tiagabine within the GAT-1 transporter, Biomolecules 2022, 12(11), 1663
• Więckowski, K.; Szałaj, N.; Gryzło, B.; Wichur, T.; Góral, I.; Sługocka, E.; Sniecikowska, J.; Latacz, G.; Siwek, A.; Godyń, J.; et al. Serotonin 5-HT6 Receptor Ligands and Butyrylcholinesterase Inhibitors Displaying Antioxidant Activity—Design, Synthesis and Biological Evaluation of Multifunctional Agents against Alzheimer’s Disease.  J. Mol. Sci.2022, 23, 9443.
• Chrienova, Z.; Rysanek, D.; Oleksak, P.; Stary, D.; Bajda, M.; Reinis, M.; Mikyskova, R.; Novotny, O.; Andrys, R.; Skarka, A.; Vasicova, P.; Novak, J.; Valis, M.; Kuca, K.; Hodny, Z.; Nepovimova, E.; Discovery of small molecule mTOR inhibitors as anti-aging and anti-cancer therapeutics, Aging Neurosci. 2022, 14: 1048260
• Szałaj, N.; Benediktsdottir, A.; Rusin, D.; Karlén, A.; Mowbray, S. M; Więckowska, A. Bacterial type I signal peptidase inhibitors – Optimized hits from nature.  J. Med. Chem.2022, 238, 11449

2021

• Godyń, J.; Zaręba, P.; Łażewska, D.; Stary, D.; Reiner-Link, D.; Frank, A.; Latacz, G.; Mogilski, S.; Kaleta, M.; Doroz-Płonka, A.; Lubelska, A.; Honkisz-Orzechowska, E.; Olejarz-Maciej, A.; Handzlik, J.; Stark, H.; Kieć-Kononowicz, K.; Malawska, B.; Bajda, M. Cyanobiphenyls: Novel H₃receptor ligands with cholinesterase and MAO B inhibitory activity as multitarget compounds for potential treatment of Alzheimer’s disease. Bioorganic Chemistry, 2021, 114, 105129
• Gryzło, G.; Zaręba, P.; Malawska, K.; Mazur, G.; Rapacz, A.; Ła̧tka, K.; Höfner, G.C.; Latacz, G.; Bajda, M.; Sałat, K.; Wanner, K.T.; Malawska, B.; Kulig, K. Novel Functionalized Amino Acids as Inhibitors of GABA Transporters with Analgesic Activity, ACS Chem. Neurosci., 2021, 12, 16, 3073–3100
• Jończyk, J.; Kukułowicz, J.; Łątka, K.; Malawska, B.; Jung, YS.; Musilek, K.; Bajda, M. Molecular Modeling Studies on the Multistep Reactivation Process of Organophosphate-Inhibited Acetylcholinesterase and Butyrylcholinesterase., Biomolecules, 2021, 11(2), 169
• Lee, HM.; Andrys, R.; Jonczyk, J.; Kim, K.; Vishakantegowda, A.G.; Malinak, D.; Skarka, A.; Schmidt, M.; Vaskova, M.; Latka, K.; Bajda, M.; Jung, Y.S.; Malawska, B.; Musilek, K. Pyridinium-2-carbaldoximes with quinolinium carboxamide moiety are simultaneous reactivators of acetylcholinesterase and butyrylcholinesterase inhibited by nerve agent surrogates. J Enzyme Inhib Med Chem, 2021, 36(1) 437-449
• Łażewska, D.; Zaręba, P.; Godyń, J.; Doroz-Płonka, A.; Frank, A.; Reiner-Link, D.; Bajda, M.; Stary, D.; Mogilski, S.; Olejarz-Maciej, A.; Kaleta, M.; Stark, H.; Malawska, B.; Kieć-Kononowicz, K. Biphenylalkoxyamine Derivatives-Histamine H₃Receptor Ligands with Butyrylcholinesterase Inhibitory Activity. Molecules. 2021, 26(12), 3580
• Rabarijoely, S.; Lech, M.; Bajda, M. Determination of Relative Density and Degree of Saturation in Mineral Soils Based on In Situ Tests. Materials (Basel). 2021, 14(22),
• Skrzypek, A.; Matysiak, J.; Karpińska, M.; Czarnecka, K.; Kręcisz, P.; Stary, D.; Kukułowicz, J.; Paw, B.; Bajda, M.; Szymański, P.; Niewiadomy, A. Bioorg Chem. 2021, 107, 104617
• Stary, D.; Kukułowicz, J.; Góral, I.; Baltrukevich, H.; Barbasevich, M.; Godyń, J.; Bajda, M. Multilevel Virtual Screening Approach for Discovery of Thymidine Phosphorylase Inhibitors as Potential Anticancer Agents.  Mol. Struct.2021, 1249, 131648
• Staszewski, M.; Nelic, D.; Jończyk, J.; Dubiel, M.; Frank, A.; Stark, H.; Bajda, M.; Jakubik, J.; Walczyński, K. Guanidine Derivatives: How Simple Structural Modification of Histamine H₃R Antagonists Has Led to the Discovery of Potent Muscarinic M₂R/M₄R Antagonists. ACS Chem Neurosci, 2021, 12(13), 2503-2519
• Wichur, T.; Pasieka, A.; Godyń, J.; Panek, D.; Góral, I.; Latacz, G.; Honkisz-Orzechowska, E.; Bucki, A.; Siwek, A.; Głuch-Lutwin, M.; Knez, D.; Brazzolotto, X.; Gobec, S.; Kołaczkowski, M.; Sabate, R.; Malawska, B.; Więckowska, A. Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HT6 receptor with anti-aggregation properties against amyloid-beta and tau. Eur J Med Chem., 2021,225, 113783
• Wichur, T.; Godyń, J.; Góral, I.; Latacz, G.; Bucki, A.; Siwek, A.; Głuch-Lutwin, M.; Mordyl, B.; Śniecikowska, J.; Walczak, M.; Knez, D.; Jukič, M.; Sałat, K.; Gobec, S.; Kołaczkowski, M.; Malawska, B.; Brazzolotto, X.; Więckowska, A.; Development and crystallography-aided SAR studies of multifunctional BuChE inhibitors and 5-HT6R antagonists with β-amyloid anti-aggregation properties. Eur J Med Chem., 2021, 225, 113792
• Zagórska, A.; Czopek, A.; Jaromin, A.; Mielczarek-Puta, M.; Struga, M.; Stary, D.; Bajda, M. Design, Synthesis, and In Vitro Antiproliferative Activity of Hydantoin and Purine Derivatives with the 4-Acetylphenylpiperazinylalkyl Moiety. Materials (Basel)., 2021, 14(15), 4156
• Zaręba, P.; Sałat, K.; Höfner, GC.; Łątka, K.; Bajda, M.; Latacz, G.; Kotniewicz, K.; Rapacz, A.; Podkowa, A.; Maj, M.; Jóźwiak, K.; Filipek, B.; Wanner, KT.; Malawska, B.; Kulig, K. Development of tricyclic N-benzyl-4-hydroxybutanamide derivatives as inhibitors of GABA transporters mGAT1-4 with anticonvulsant, antinociceptive, and antidepressant activity. Eur J Med Chem. 2021, 221, 113512