Faculty of Pharmacy

Research

Research topics
The leading scientific specialization developed in the Chair of Medicinal Plant and Mushroom Biotechnology (formerly in the Department of Pharmaceutical Botany) for a number of years has been plant biotechnology with elements of phytochemistry. Research in this area includes in vitro cultures of medicinal and/or cosmetic plants. Most of the work deals with endogenous and stimulated by exogenous precursors and/or elicitors (stress factors) accumulation of bioactive metabolites in in vitro cultures. The studied groups of bioactive compounds are: phenolic acids, citric lignans, flavonoids, including Scutellaria genus-specific compounds, phenylpropanoid glycosides (including verbascoside), tannin precursors – catechin derivatives and sulfur-containing compounds. Research is also being conducted on the biotransformation of precursors into therapeutically important products with the participation of plant enzymes of cells from in vitro cultures. Most of the research is concerned with the biotransformation of simple phenolic compounds – hydroquinone and 4-hydroxybenzoic acid into arbutin (β-D-glucoside of hydroquinone) The entire research is aimed at proposing in vitro cultures as a valuable source for obtaining biologically active compounds.
In order to evaluate the biosynthetic potential of cells from in vitro cultures, work of a phytochemical nature is carried out on the analysis of bioactive compounds in plant organs growing in vivo.
Another important scientific specialization developed in the Chair of Medicinal Plant and Mushroom Biotechnology for a number of years is mycochemistry and biotechnology of higher mushrooms. Within the framework of the aforementioned scientific specialties, research is conducted on the content of actively biological compounds in the fruiting bodies of higher mushrooms (Basidiomycota) as well as in their in vitro cultures (so-called mycelial cultures). The groups of compounds studied are: non-hallucinogenic indole compounds, phenolic acids, sterols, fatty acids and polysaccharides. The goal of mycochemical research is to scientifically prove the medicinal and dietary values of higher mushrooms, while the goal of fungal biotechnology research is to propose mycelial cultures as a rich, alternative source for obtaining bioactive metabolites. A new scientific issue of interest is the study of the accumulation and release of bioelements from fruiting bodies and in vitro cultures of edible mushrooms.
Another direction of research is the evaluation of dietary supplement preparations containing selected algae species in terms of their chemical composition and the degree of release of biologically active substances into artificial digestive juices.
All the above-mentioned research in the fields of plant biotechnology, phytochemistry, mycochemistry and fungal biotechnology is carried out in cooperation with domestic and foreign scientific centers.

Methods

  • Establishment of in vitro cultures of medicinal and/or cosmetic plant species and mycelial cultures of higher mushrooms.
  • Optimization of in vitro culture conditions, among others, testing the composition of culture media, type of culture, light conditions.
  • Lyophilization of plant and fungal material.
  • Extraction of plant and fungal material with solvents of different polarity.
  • Quantitative analysis of active compounds by high-pressure liquid chromatography (HPLC).
  • Isolation of selected compounds and their identification by spectral methods (ESI-MS and 1H-NMR spectra).
  • Study of antioxidant properties of biomass extracts from in vitro cultures and mother plants by FRAP, DPPH, CUPRAC and QUENCHER CUPRAC methods (in collaboration).

Research Apparatus

  • Isocratic kit for high-performance liquid chromatography HPLC
  • High performance liquid chromatography apparatus with autosampler and detector
  • DYNEX microplate analyzer
  • SYNERGY H1 multifunctional microplate reader with control station
  • BIOLOGIX D1008 mini-centrifuge
  • CENTRIVAP vacuum concentrator

Grants and other research projects

NCN grants

  • NCN Grant “Sonata” (Contract No: UMO-2016/23/D/NZ7/01316) – “Phytochemical, biotechnological studies and evaluation of biological activity of the species Schisandra rubriflora”. Project manager: prof. dr. Agnieszka Szopa – 2017-2020.
  • NCN “Prelude” Grant (Contract No: UMO-2017/25/N/NZ7/00554) – “Study of the release and absorption into the human body of bioelements and biologically active organic compounds from the fruiting bodies and biomass of selected edible medicinal mushrooms”. Project Manager: Katarzyna Kała, MS – 2017-2019.
  • NCN grant “Prelude” (Contract number: UMO-2020/37/N/NZ7/02436) – “Schisandra henryi B. Clarke – increasing the production of secondary metabolites by biotechnological methods and evaluating the biological activity of the material extracted in vitro and in vivo”. Project Manager: Karolina Jafernik, MA – 2021-2023.
  • NCN “Opus” Grant (Contract No.: UMO-2023/49/B/NZ7/02428) – “Do metal nanoparticles affect the biosynthesis of bioactive plant metabolites? – Studies on in vitro culture model of health-promoting Brassicaceae species”. Project Manager: Prof. Dr. Agnieszka Szopa – 2024-2028.

Student grants

  • Student Grant – “Application of immobilized in vitro cultures of selected species of white wood rot mushrooms and microalgae of the Chlorophyta cluster in biodegradation of xenoestrogens” – carried out by Jan Lazur, member of the Scientific Student Circle operating in the Chair of Medicinal Plant and Mushroom Biotechnology at UJ-CM – 2018-2019.
  • Student grant – “Fortified with bio-elements mycelia and fruiting bodies of selected medicinal mushroom species” – implemented by Jan Lazur, member of the Scientific Student Circle operating in the Chair of Medicinal Plant and Mushroom Biotechnology at UJ-CM – 2021-2022.

Projects within the framework of Commercial Contractual Activity (KDU)

  • Project K/KDU/000507 – “Shaping the immune response in calves using innovative preparations containing silicon nanoparticles and modified cultures of Lentinula edodes.” – 2018 r.
  • Project K/KDU/000499 – “Development of innovative cosmetic products using stem cells by AERO BW”. – 2019 r.
  • Project K/KDU/000710 – “Recognition of Sodium Butyrate, Cinnamon, Turmeric, Green Tea and Fenugreek and its unique nature in blood sugar regulation and insulin resistance” – 2021.
  • Project K/KDU/000719 – “Analysis of the 5-hydroxytryptophan content of the dietary supplement MushUp containing Hericium erinaceus mycelium” – 2021.
  • Project K/KDU/00033 – “Preparation of opinions on the preparation made from mycelium prepared by Cavendish Acquisitions in terms of antiviral and antidepressant activity, together with possible indications on the possibility of modifying the preparation” – 2021-2022.
  • Project K/KDU/00037 – “Obtaining fortified mycelium of Fomitopsis officinalis” – 2021-2023.
  • Project K/KDU/000701 – “Determination of the content of biologically active substances in extracts from fruiting bodies of Lentinula edodes”. – 2021-2024 r.
  • Projekt K/KDU/000804 – “Performance of multiplication of mycelium of Pycnoporelus fulgens by biotechnological methods”. – 2022-2024.
  • Project K/KDU/000855 – “Analysis of the content of phenolic compounds (phenolic acids, flavonoids, catechins) and some amino acids of Nigella damascena” – 2023-2024.
  • Project K/KDU/000869 – “Consultation and scientific support for the development of an innovative nutraceutical formula based on natural resources with procognitive effects” – 2023-2024.

Other projects

  • Project from a grant from the Ministry of Agriculture and Rural Development to cover the costs of research for organic farming incurred in 2023. – “Field cultivation by organic methods: research in organic cultivation of edible forest mushrooms” – 2023.
  • Project from a grant from the Agency for the Restructuring and Modernization of Agriculture under Measure M16 “Cooperation” of the Rural Development Program 2014-2020 – “Development of an innovative method of cultivation of Lentinula edodes and Hericium erinaceus mushrooms using hemp straw as a substrate and development of technology for production of medicinal mushroom extracts containing the full spectrum of active compounds” – 2023-2024.

Patents and patent applications

  • Patent No. 238239 – “Device for testing physiologically active substances”. Co-authors of the invention: Opoka W., Muszyńska B., Rojowski J., Rumian J. – 2021.
  • Patent No. 241427 – “Stimulant preparation”. Co-inventors of the invention: Pieszka M. P., Bederska-Łojewska D., Pierzynowski S. G., Muszyńska B. – 2022 r.
  • Patent application P.432076 – “Mushroom-selenium feed additive, its preparation and use in improving the condition of livestock”. Co-authors of the application: Muszyńska B., Lazur J., Kała K., Kubica P., Suchocki P., Bederska-Łojewska D., Pieszka M., Szacawa E., Dudek K., Bednarek D. – 2020 r.
  • Patent application PPL1259AGR – “Method of obtaining fortified mycelium of Fomitopsis officinalis, active substances contained therein, compositions containing them and their health-promoting applications”. Co-authors of the application: Muszyńska B., Sułkowska-Ziaja K., Krakowska A., Fijałkowska A. – 2021 r.
  • Patent No. P590 – “Method of stimulating biosynthesis of health-promoting bioactive compounds in an in vitro culture model of Brassica oleracea var. acephala (green kale)”. Co-authors of the application: Szopa A., Jafernik K., Klimek-Szczykutowicz M., Ekiert H., Żmudzki P., Paśko P., Dziurka M., Blicharska E., Tatarczak-Michalewska M., Błażewicz A., Czarnek K. – 2024 r.
  • Patent application P633 – “Aeration and mixing device for stationary mycelium culture, a bioreactor using it and a method for stationary mycelium culture”. Co-authors: Kubica P., Muszyńska B. – 2024 r.

Publications
Original publications 2024
1. Lazur J., Kała K., Krakowska A., Sułkowska-Ziaja K., Szewczyk A., Piotrowska J., Rospond B., Fidurski M., Marzec K., Muszyńska B.: Analysis of bioactive substances and essential elements of mycelia and fruiting bodies of Hericium ssp. Journal of Food Composition and Analysis, 127, 105981, 2024.
2. Czarnek K., Tatarczak-Michalewska M., Szopa A., Klimek-Szczykutowicz M., Jafernik K., Majerek D., Blicharska E.: Bioaccumulation capacity of onion (Allium cepa L.) tested with heavy metals in biofortification. Molecules, 29(1), 101, 2024.
3. Nunes R., Carvalho I. S., Paśko P., Tyszka-Czochara M., Szewczyk A., Szlósarczyk M., Podolak I., Galanty A.: In vitro biological activity screening of Arbutus unedo leaves in light of their traditional use. Journal of Herbs, Spices & Medicinal Plants, 30(1), 68-82, 2024.
4. Jafernik K., Kubica P., Dziurka M., Kulinowski Ł., Korona-Głowniak I., Elansary H. O., Waligórski P., Skalicka-Woźniak K., Szopa A.: Comparative assessment of lignan profiling and biological activities of Schisandra henryi leaf and in vitro Plantform bioreactor-grown culture extracts. Pharmaceuticals, 17(4), 442, 2024.
5. Borczak B., Szewczyk A., Domagała D., Kapusta-Duch J., Leszczyńska T., Kotuła M., Grulova D.: Potential antidiabetic, antioxidative and antiproliferative properties of functional wheat flour muffins enriched with white clover flowers (Trifolium repens L.). International Journal of Molecular Sciences, 25, 9909, 2024.
6. Michalak M., Błońska-Sikora E., Stryjecka M., Zagórska-Dziok M., Klimek-Szczykutowicz M., Szopa A.: Phytochemical profile and antioxidant and protective activities of various types of extracts from Hyssopus officinalis L. and Grindelia robusta Nutt. herb grown in Poland. Current Topics in Medicinal Chemistry, 25, 2238-2253, 2024.
7. Makowski W., Mrzygłód K., Szopa A., Kubica P., Krychowiak-Maśnicka M., Tokarz K. M., Tokarz B., Ryngwelska I., Paluszkiewicz E., Królicka A.: Effect of agitation and temporary immersion on growth and synthesis of antibacterial phenolic compounds in genus Drosera. Biomolecules, 14(9), 1132, 2024.
8. Jafernik K., Kubica P., Sharafan M., Kruk A., Malinowska M. A., Granica S., Szopa A.: Phenolic compound profiling and antioxidant potential of different types of Schisandra henryi in vitro cultures. Applied Microbiology and Biotechnology, 108(1), 322, 2024.
9. Motyka S., Szopa A., Ochatt S. J.: Distinction of chia varieties in vivo and in vitro based on the flow cytometry and rosmarinic acid production. Applied Microbiology and Biotechnology, 108(1), 337, 2024.
10. Rząsa-Duran E., Muszyńska B., Szewczyk A., Kała K., Sułkowska-Ziaja K., Piotrowska J., Opoka W., Kryczyk-Poprawa A.: Ilex paraguariensis extracts: a source of bioelements and biologically active compounds for food supplements. Applied Sciences, 14(16), 7238, 2024.
11. Kała K., Cicha-Jeleń M., Hnatyk K., Krakowska A., Sułkowska-Ziaja K., Szewczyk A., Lazur J., Muszyńska B.: Coffee with Cordyceps militaris and Hericium erinaceus fruiting bodies as a source of essential bioactive substances. Pharmaceuticals, 17(7), 955, 2024.
12. Nicosia N., Kwiecień I., Bednarski M., Głuch-Lutwin M., Mordyl B., Mika K., Hambaryan R., Miller A., Alesci A., Lauriano E. R., Zammit P., Ragusa S., Trojan E., Fumia A., Sapa J., Miceli N., Kotańska M.: Anti-diabetes and neuroprotection potential and primary safety studies of Isatis tinctoria L. hydroalcoholic leaf extract. Fitoterapia, 177, 106138, 2024.
13. Jędrejko K., Kała K., Sułkowska-Ziaja K., Krakowska A., Szewczyk A., Guśpiel K., Muszyńska B.: Analysis of bioactive compunds in Cordyceps militaris fruiting bodies and dietary supplements: in vitro bioaccessibility determination in artificial digestive juices. International Journal of Food Sciences and Technology, 59(6), 4011-4019, 2024.
14. Krakowska A., Suchanek M., Piech R., Paczosa-Bator B., Skalski T., Muszyńska B.: Accumulation of Bisphenol A by Pleurotus spp. – flow injection analysis. Molecules, 29(11), 2520, 2024.
15. Szewczyk A., Trepa M., Zych D.: Optimization of the production of secondary metabolites from furanocoumarin and furoquinoline alkaloid groups in in vitro Ruta corsica cultures grown in temporary immersion bioreactors. Molecules, 29, 5261, 2024.
16. Duliński R., Byczyński Ł., Kwiecień I., Karbowski A.: Analiza wybranych parametrów bioaktywnych czarnego czosnku uzyskanego w krótkim trybie fermentacji. Żywność. Nauka. Technologia. Jakość, 31(138), 148-159, 2024.
17. Dziki A., Malinowska M. A., Szopa A., Sikora E.: Comparative study of the phytochemical profile and biological activity of Ajuga reptans L. leaf and root extracts. Applied Sciences, 14, 5105, 2024.
18. Makowski W., Królicka A., Sroka J., Matyjewicz A., Potrykus M., Kubica P., Szopa A., Tokarz B., Tokarz K. M.: Agitated and temporary immersion bioreactor cultures of Reynoutria japonica Hutt. as a rich source of phenolic compunds. Plant Cell, Tissue and Organ Culture, 158, 45, 2024.
19. Kubica P., Szopa A., Setkiewicz A., Ekiert H.: Efficient production of some bioactive depsides and simple phenolic acids by microshoots of Aronia x prunifolia (purple aronia) agitated cultures as the result of feeding strategy with four different biogenetic precoursors. Molecules, 29(19), 4622, 2024.
20. Jafernik K., Kokotkiewicz A., Dziurka M., Kruk A., Hering A., Jędrzejewski K., Waligórski P., Graczyk P., Kubica P., Szopa A.: Phytochemical profiling and biological activities of extracts from bioreactor-grown suspension cell cultures of Schisandra henryi. Molecules, 29(22), 5260, 2024.
21. Gozdur K., Szopa A., Ślesak H.: Effect of salt stress on growth and phenolic compounds production in callus suspesion culture of the dioecious species thyrse sorrel (Rumex thyrsiflorus Fingerh.). Plant Cell, Tssue and Organ Culture, 158(3), 54, 2024.
22. Ptak A., Szewczyk A., Simlat M., Pawłowska B., Warchoł M.: LED light improves shoot multiplication, steviol glycosides and phenolic compounds biosynthesis in Stevia rebaudiana Bertoni in vitro culture. Scientific Reports, 14, 30860, 2024.

Original publictions 2023
1. Szewczyk A., Paździora W., Ekiert H.: The influence of exogenous phenylalanine on the accumulation of secondary metabolites in agitated shoot cultures of Ruta graveolens L. Molecules, 28(2), 727, 2023.
2. Sułkowska-Ziaja K., Galanty A., Szewczyk A., Paśko P., Kała K., Apola A., Podolak I., Muszyńska B.: Effect of methyl jasmonate elicitation on triterpene production and evaluation of cytotoxic activity of mycelial culture extracts of Ganoderma applanatum (Pers.) Pat. Plants, 12(2), 294, 2023.
3. Simlat M., Ptak A., Jaglarz A., Szewczyk A., Dziurka M., Gurgul A.: Seeds of Stevia rebaudiana Bertoni as a source of plant growth-promoting endophytic bacteria with the potential to synthesize rebaudioside A. International Journal of Molecular Sciences, 24(3), 2174, 2023.
4. Simlat M., Ptak A., Wójtowicz T., Szewczyk A.: The content of phenolic compounds in Stevia rebaudiana (Bertoni) plants derived from melatonin and NaCl treated seeds. Plants, 12(4), 780, 2023.
5. Szewczyk A., Grabowski M., Zych D.: Ruta chalepensis L. in vitro cultures as a source of bioactive furanocoumarins and furoquinoline alkaloids. Life, 13(2), 457, 2023.
6. Michalak M., Zagórska-Dziok M., Klimek-Szczykutowicz M., Szopa A.: Phenolic profile and comparison of the antioxidant, anti-ageing, anti-inflammatory, and protective activities of Borago officinalis extracts on skin cells. Molecules, 28(2), 868, 2023.
7. Kwiecień I., Miceli N., Kędzia E., Cavo E., Taviano M. F., Beerhues L., Ekiert H.: Different types of Hypericum perforatum cvs. (Elixir, Helos, Topas) in vitro cultures: a rich source of bioactive metabolites and biological activities of biomass extracts. Molecules, 28(5), 2376, 2023.
8. Kwiecień I., Łukaszyk A., Miceli N., Taviano M. F., Davi F., Kędzia E., Ekiert H.: In vitro cultures of Scutellaria brevibracteata subsp. subvelutina as a source of bioactive phenolic metabolites. Molecules, 28(4), 1785, 2023.
9. Motyka S., Kusznierewicz B., Ekiert H., Korona-Głowniak I., Szopa A.: Comparative analysis of metabolic variations, antioxidant profiles and antimicrobial activity of Salvia hispanica (Chia) seed, sprout, leaf, flower, root and herb extracts. Molecules, 28(6), 2728, 2023.
10. Makowski W., Królicka A., Tokarz B., Szopa A., Ekiert H., Tokarz K. M.: Temporary immersion bioreactors as a useful tool for obtaining high productivity of phenolic compounds with strong antioxidant properties from Pontechium maculatum. Plant Cell, Tissue and Organ Culture, 153(3), 525-537, 2023.
11. Miceli N., Kwiecień I., Nicosia N., Speranza J., Ragusa S., Cavo E., Davi F., Taviano M. F., Ekiert H.: Improvement in the biosynthesis of antioxidant-active metabolites in in vitro cultures of Isatis tinctoria (Brassicaceae) by biotechnological methods/elicitation and precursor feeding. Antioxidants, 12(5), 1111, 2023.
12. Czech K., Gaweł-Bęben K., Szopa A., Kukula-Koch W., Jakschitz T., Bonn G., Hussain S., Kubica P., Ekiert H., Głowniak K.: Phytochemical profiling, antioxidant and tyrosinase regulatory activities of extracts from herb, leaf and in vitro culture of Achillea millefolium (Yarrow). Molecules, 28(12), 4791, 2023.
13. Budzianowska A., Derda M., Budzianowski J., Szopa A., Kikowska M.: Comparative study of Plantago media extracts in the treatment of Acanthamoeba sp. Trophozoites. Applied Sciences, 13(12), 7075, 2023.
14. Sułkowska-Ziaja K., Robak J., Szczepkowski A., Gunia-Krzyżak A., Popiół J., Piotrowska J., Rospond B., Szewczyk A., Kała K., Muszyńska B.: Comparison of bioactive secondary metabolites and cytotoxicity of extracts from Inonotus obliquus isolates from different host species. Molecules, 28(13), 4907, 2023.
15. Pałka P., Muszyńska B., Szewczyk A., Pawłowska B.: Elicitation and enhancement of phenolics synthesis with zinc oxide nanoparticles and LED light in Lilium candidum L. cultures in vitro. Agronomy, 13(6), 1437, 2023.
16. Fijałkowska A., Rychlik M., Krakowska A., Muszyńska B.: Effects of dietary supplementation with in vitro-cultivated arboreal medicinal mushrooms on long-term memory and anxiety-like behavior of male mice. International Journal of Medicinal Mushrooms, 25(5), 49-60, 2023.
17. Nunes R., Carvalho I. S., Paśko P., Tyszka-Czochara M., Szewczyk A., Szlósarczyk M., Podolak I., Galanty A.: In vitro biological activity screening of Arbutus unedo leaves in light of their traditional use. Journal of Herbs, Spices and Medicinal Plants, 2023.
18. Szewczyk A., Marino A., Taviano M. F., Cambria L., Davi F., Trepa M., Grabowski M., Miceli N.: Studies on the accumulation of secondary metabolites and evaluation of biological activity of in vitro cultures of Ruta montana L. in temporary immersion bioreactors. International Journal of Molecular Sciences, 24(8), 7045, 2023.
19. Czarnek K., Tatarczak-Michalewska M., Dreher P., Rajput V. D., Wójcik G., Gierut-Kot A., Szopa A., Blicharska E.: UV-C seed surface sterilization and Fe, Zn, Mg, Cr biofortification of wheat sprouts as an effective strategy of bioelement supplementation. International Journal of Molecular Sciences, 24(12), 10367, 2023.
20. Ptak A., Szewczyk A., Simlat M., Błażejczak A., Warchoł M.: Meta-Topolin-induced mass shoot multiplication and biosynthesis of valuable secondary metabolites in Stevia rebaudiana Bertoni bioreactor culture. Scientific reports, 13(1), 15520, 2023.
21. Sobstyl E., Szopa A., Olszowy-Tomczyk M., Gnat S., Jafernik K., Choma I. M.: Chromatographic and biological screening of chosen species of Schisandraceae family: Schisandra chinensis, S. rubriflora, S. sphenanthera, S. henryi and Kadsura japonica. Chemistery & Biodiversity, 20, e202300741, 2023.

Cooperation
Cooperation with National Centers

  • Department of Phytochemistry, Institute of Pharmacology, Polish Academy of Sciences, Krakow
  • Department of Clinical and Industrial Toxicology, Toxicology Clinic, UM-CM
  • Department of Pharmacognosy, Medical University of Gdansk
  • Laboratory of Biologically Active Compounds Research, Department of Biotechnology, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk
  • Department of Pharmaceutical Biology and Biotechnology, Medical University of Lodz
  • Department and Department of Practical Cosmetology and Skin Disease Prevention, Laboratory of Pharmaceutical Biology and Biotechnology, Medical University of Lodz Karol Marcinkowski in Poznań
  • Institute of Natural Fibres and Medicinal Plants in Poznań
  • Department of Cosmetology, University of Information Technology and Management in Rzeszów
  • Institute of Plant Physiology of the Polish Academy of Sciences in Kraków
  • Department of Ornamental Plants of the H. Kołłątaj University of Agriculture in Kraków
  • Władysław Szafer Institute of Botany of the Polish Academy of Sciences in Kraków
  • Department of Organic Chemistry and Technology, Faculty of Chemical Engineering and Technology, Kraków University of Technology Tadeusz Kościuszko in Krakow
  • Department of Plant Physiology and Biochemistry of the Faculty of Biotechnology of the Jagiellonian University
  • Department of Clinical and Environmental Allergology of the Jagiellonian University Medical College
  • Cooperation with the Units of the Faculty of Pharmacy of the Jagiellonian University Medical College (Department of Bromatology, Department of Inorganic and Analytical Chemistry, Department of Pharmaceutical Biochemistry) and with the Units of the Faculty of Medicine of the Jagiellonian University Medical College (Department of Medical Biochemistry, Department of Virology)

Cooperation with Foreign Centers

  • Institut für Pharmazeutische Biologie, Rheinische Friedrich-Wilhelms-Universität Bonn
  • Institut für Pharmazeutische Biologie, Technische Universität Braunschweig
  • Lehrstuhl Technische Biochemie, FK Bio- und Chemieingenieurwesen, Technische Universität Dortmund
  • Austrian Drug Screening Institute (ADSI) and Centrum für Chemie und Biomedizin (CCB), Innsbruck, Austria
  • Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina
  • Biomolécules et Biotechnologies Végétales, Sciences et Techniques Parc de Grandmont, Université François Rabelais, Tours
  • Department of Organic Chemistry, Faculty of Chemistry and Technology, University of Split
  • Szegedi Tudományegyetem (University of Szeged)
  • French National Institute for Agriculture, Food, and Environment, Dijon
  • University of Barcelona

Keywords

  • plant biotechnology, biotechnology of higher mushrooms, secondary metabolites, phytochemical analysis, mycochemical analysis

 

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