Research Topics

The research themes of scientific works are focused on developing and evaluating modern forms in the field of pharmaceutical technology, including biopharmaceutical aspects. In light of new research directions, experimental work is being conducted on, among other things, developing new drug forms or their modifications to ensure appropriate quality and safety of use in patients. The main research directions include:
1. technological aspects of improving the pharmaceutical availability of very difficult and practically insoluble medicinal substances,
2. optimization of modern drug forms in the form of: multicompartment systems, tablets and films disintegrating in the oral cavity (ODT, ODF), tablets with a liquid fraction,
3. optimization of drug forms with modified release of medicinal substances based on basic science knowledge,
4. designing drug forms in the aspect of personalized therapy,
5. evaluation of the physicochemical properties of excipients to optimize the technology of manufacturing oral drug forms using modern analytical methods,
6. application of incremental forming tools (3D printing) as a platform for innovative technological solutions.
7. designing research methods to ensure the quality of modern drug forms,
8. decision support systems to optimize the manufacturing strategies of medicinal products based on computational intelligence tools,
9. innovative solutions in drug form design through the use of Quality by Design and Process Analysis Technology principles.


Applied Methods

  1. Qualitative studies characteristic of drug forms

  2. In vitro pharmaceutical availability studies

  3. Physicochemical studies of solid and dispersed systems

  4. Modeling release processes using artificial intelligence


Research Equipment

The laboratory and equipment facilities of the Department provide the opportunity to conduct research in a broad range, including technological and analytical work aimed at assessing the quality of drug forms. Among the most important elements of the Department’s equipment are production equipment, which is used for laboratory-scale preparation of various drug forms.

From the perspective of implementing research projects, significant devices available in the unit include impact and rotary tablet presses: Korsch EK0, Korsch PH 103, Erweka TRB 10, allowing for the production of ODT tablets and tablets with pellets, a set for extrusion and spheronization: Alexanderwerk GA 60 extruder, Caleva 120 spheronizer, high-speed FS-GS Fukae Powtec granulator, fluid bed apparatus for granulation, drying, and coating: Bosch-Solidlab and 4M8-F Pro-C-epT, Buchi B-191 spray dryer, Elcometer 4340 device for producing polymer films of precisely defined thickness, Fritsch Pulverisette 7 Classic Line and Premium Line planetary mills, twin-screw melt extruder RES-2P/12A Explorer, Zamak Mercator®, Skawina; equipped with a gravimetric feeder MCPOWDER® Movacolor®, Sneek, the Netherlands, and a cooled transmission belt Zamak Mercator®, Skawina. 3D printers: ZMorph 2.0S, ZMorph VX, Flashforge Adventurer 4.

The Department also has a wide range of research equipment used to assess drug forms, including: sets for testing the release of medicinal substances (apparatus 1 and 2 according to FP): Hanson SR8 water bath and Dissoette II fraction collector and Hanson Research Elite 8 Vision G2, a set for testing the release of medicinal substances by the flow-through method (apparatus 4 according to FP) Erweka DFZ 60 with HKP 60 pump, PharmaTest PTF-E friabilometer,  VanKel VK 200 hardness tester, Electrolab ED-2 SAPO disintegration time tester, spectrophotometers: UV-VIS JASCO V-530 and Schimadzu UV-1800 UV-VIS, set for high-performance liquid chromatography HPLC Agilent 1260 Infinity, Malvern Mastersizer 3000 device for particle size measurement by laser diffraction, Schimadzu EZ-SX texture analyzer, Haake VT 550 rheometer, optical microscopes: Hund Wetzlar H600 and MST-ZOOM PZO,



  • Urszula Bąk, Anna Krupa: Challenges and opportunities for celecoxib repurposing , Pharmaceutical Research, 2023, DOI:10.1007/s11095-023-03571-4 [in print], 70 points, IF(3,7)
  • Witold Brniak, Justyna Srebro, Klaudia Syty, Katarzyna Tomaś, Renata Jachowicz: Pediatryczne biofarmaceutyczne systemy klasyfikacji leków (pBCS), Farmacja Polska, vol. 79, nr 6, 2023, s. 367-375, DOI:10.32383/farmpol/174417, 140 points
  • Natalia Czub, Jakub Szlęk, Adam Pacławski, Klaudia Klimończyk, Matteo Puccetti, Aleksander Mendyk: Artificial intelligence-based quantitative structure-property relationship model for predicting human intestinal absorption of compounds with serotonergic activity, Molecular Pharmaceutics, American Chemical Society, vol. 20, no. 5, 2023, p. 2545-2555, DOI:10.1021/acs.molpharmaceut.2c01117, 140 points, IF(4,9)
  • Yuri Dancik, Naresh Mittapelly, Santosh K. Puttrevu, Sebastian Polak: A novel physiologically based pharmacokinetic model of rectal absorption, evaluated and verified using clinical data on 10 rectally administered drugs, International Journal of Pharmaceutics, vol. 643, 2023, Article Number: 123273, DOI:10.1016/j.ijpharm.2023.123273, 100 points, IF(5,8)
  • Alicja Gawalska, Natalia Czub, Michał Sapa, Marcin Kołaczkowski, Adam Bucki, Aleksander Mendyk: Application of automated machine learning in the identification of multi‐target‐directed ligands blocking PDE4B, PDE8A, and TRPA1 with potential use in the treatment of asthma and COPD, Molecular Informatics, vol. 42, no. 7, 2023, Article Number: 2200214, DOI:10.1002/minf.202200214, 70 points, IF(3,6)
  • Anna Górska, Aleksander Mendyk: Hydrożele jako skuteczne materiały opatrunkowe we wspomaganiu leczenia ran, Farmacja Polska, vol. 79, nr 4, 2023, s. 217-225, DOI:10.32383/farmpol/172007, 140 points
  • Justyna Knapik-Kowalczuk, Daniel Kramarczyk, Renata Jachowicz, Marian Paluch: Effect of shear strain on the supercooled itraconazole, Journal of Pharmaceutical Sciences, vol. 112, no. 6, 2023, p. 1644-1652, DOI:10.1016/j.xphs.2023.01.020, 70 points, IF(3,8)
  • Daniel Kramarczyk, Justyna Knapik-Kowalczuk, Mateusz Kurek, Witold Jamróz, Renata Jachowicz, Marian Paluch: Hot melt extruded posaconazole-based amorphous solid dispersions – the effect of different types of polymers, Pharmaceutics, MDPI, vol. 15, no. 3, 2023, Article Number: 799, DOI:10.3390/pharmaceutics15030799, 140 points, IF
  • Krupa Anna, Danede Florence, Majda Dorota, Węgrzyn Agnieszka, Strojewski Dominik, Kondera Ita, Willart Jean-Francois: High energy ball milling vs. nano spray drying in the development of supersaturated systems loaded with bosentan, European Journal of Pharmaceutics and Biopharmaceutics, Elsevier BV, vol. 188, 2023, s. 137-146, DOI:10.1016/j.ejpb.2023.05.014, 100 punktów, IF(4,9)
  • Kubat Karol, Krupa Anna, Brniak Witold, Węgrzyn Agnieszka, Majda Dorota, Bogdał Agata, Harańczyk Hubert: How rotational speed of planetary ball mill and polymer load influence the performance and water vapor sorption in solid dispersions composed of tadalafil and soluplus, Particuology, vol. 73, 2023, s. 37-46, DOI:10.1016/j.partic.2022.04.003, 100 punktów, IF(3,5)
  • Kubat Karol, Strojewski Dominik, Majda Dorota, Jakubiec Daniel, Andrzejowska Aleksandra, Bogdał Agata, Krupa Anna, Harańczyk Hubert: Molecular phenomena related to moisture uptake in amorphous solid dispersion loaded with bosentan monohydrate and copovidone, Powder Technology, Elsevier, vol. 430, 2023, Numer artykułu: 119020, DOI:10.1016/j.powtec.2023.119020, 140 punktów, IF(5,2)
  • Łyszczarz Ewelina, Jachowicz Renata: Filmy ulegające rozpadowi w jamie ustnej – charakterystyka metod oceny ich jakości , Farmacja Polska, vol. 79, nr 8, 2023, s. 453-461, DOI:10.32383/farmpol/176197, 140 punktów
  • Maciejewska Aldona, Niwiński Krzysztof, Kornaus Kamil, Rutkowski Paweł: Praktyczne aspekty stosowania podłoża Witepsol H15 w recepturze aptecznej , Farmacja Polska, vol. 79, nr 7, 2023, s. 421-429, DOI:10.32383/farmpol/174889, 140 punktów
  • Maślanka Anna, Szlósarczyk Marek, Talik Przemysław, Szafraniec-Szczęsny Joanna, Woyna-Orlewicz Krzysztof, Żmudzki Paweł, Hubicka Urszula: Study of the effect of eudragit RSPO on the photostability of venlafaxine in a physical mixture and in a melt form , Processes, MDPI, vol. 11, nr 8, 2023, Numer artykułu: 2479 , DOI:10.3390/pr11082479, 100 punktów, IF(3,5)
  • Pyteraf Jolanta, Jamróz Witold, Kurek Mateusz, Bąk Urszula, Loskot Jan, Kramarczyk Daniel, Paluch Marian, Jachowicz Renata: Preparation and advanced characterization of highly drug-loaded, 3D printed orodispersible tablets containing fluconazole, International Journal of Pharmaceutics, vol. 630, 2023, Numer artykułu: 122444, DOI:10.1016/j.ijpharm.2022.122444, 100 punktów, IF(5,8)
  • Staniszewska Marcela, Romański Michał, Polak Sebastian, Garbacz Grzegorz, Dobosz Justyna, Myslitska Daria, Romanova Svitlana, Paszkowska Jadwiga, Danielak Dorota: A Rational approach to predicting immediate release formulation behavior in multiple gastric motility patterns : a combination of a biorelevant apparatus, design of experiments, and machine learning , Pharmaceutics, MDPI, vol. 15, nr 8, 2023, Numer artykułu: 2056 , DOI:10.3390/pharmaceutics15082056, 140 punktów, IF(5,4)
  • Tranová Thao, Loskot Jan, Navrátil Ondřej, Brniak Witold, Mužíková Jitka: Effect of co-processed excipient type on properties of orodispersible tablets containing captopril, tramadol, and domperidone, International Journal of Pharmaceutics, vol. 636, 2023, Numer artykułu: 122838, DOI:10.1016/j.ijpharm.2023.122838, 100 punktów, IF(5,8)
  • Tsakalozou Eleftheria, Mohamed Mohamed-Eslam F., Polak Sebastian, Heimbach Tycho: Applications of modeling and simulation approaches in support of drug product development of oral dosage Forms and locally acting drug products : a symposium summary, AAPS Journal, vol. 25, nr 6, 2023, Numer artykułu: 96, DOI:10.1208/s12248-023-00862-x
  • Woyna-Orlewicz Krzysztof, Brniak Witold, Tatara Wiktor, Strzebońska Magdalena, Haznar-Garbacz Dorota, Szafraniec-Szczęsny Joanna, Antosik-Rogóż Agata, Kurek Mateusz, Jachowicz Renata, Mendyk Aleksander: Investigating the impact of co-processed excipients on the formulation of bromhexine hydrochloride orally disintegrating tablets (ODTs), Pharmaceutical Research, 2023, DOI:10.1007/s11095-023-03605-x, łączna liczba autorów: 12 [w druku], 70 punktów, IF(3,7)
  • Wyszogrodzka-Gaweł Gabriela, Shuklinova Olha, Lisowski Bartek, Wiśniowska Barbara, Polak Sebastian: 3D printing combined with biopredictive dissolution and PBPK/PD modeling optimization and personalization of pharmacotherapy : Are we there yet?, Drug Discovery Today, vol. 28, nr 10, 2023, Numer artykułu: 103731, DOI:10.1016/j.drudis.2023.103731, 200 punktów, IF(7,4).

Archival publications:


Partnerships and collaboration


National Partnerships and Collaboration

  • Politechnika Warszawska – Laboratorium Technologii Materiałów Leczniczych
  • Politechnika Warszawska – Zakład Chemii Analitycznej
  • Politechnika Warszawska – Wydział Chemiczny
  • Politechnika Gdańska – Katedra Technologii Polimerów i Chemii Medycznej
  • Uniwersytet Gdański – Katedra Chemii Medycznej


International Collaboration and Partnerships

  • Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, Hungary
  • School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore
  • Department of Chemical and Process Engineering, University of Surrey, United Kingdom
  • Institute of Pharmaceutical Technology Düsseldorf, Germany
  • Centre National de la Recherche Scientifique, Ecole des Mines d’Albi, Albi, France
  • AstraZeneca, Macclesfield, United Kingdom
  • Fraunhofer Institute, Germany
  • Johnson Matthey Ltd., United Kingdom
  • Faculty of Electrical Engineering and Computer Science Vysoka Skola Banska, Czech Republic
  • Machine Intelligence Research (MIR) Labs, Czech Republic
  • Research Center Pharmaceutical Engineering GmbH, Graz, Austria
  • Department of Computer Science, Babes-Bolyai University, Romania
  • Department of Chemical Drugs, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic
  • Université Lille2 Nord de France, INSERM U1008, College of Pharmacy, Lille, France
  • Université Lille1 Nord de France, CNRS UMR 8207, Unité Matériaux et Transformations, Villeneuve d’Ascq, France
  • Department of Physics, Faculty of Science, University of Hradec Králové
  • Department of Pharmaceutical Technology, Faculty of Pharmacy, Charles University in Hradec Králové 


International Projects









National Projects







• oral solid dosage forms • pellets • floating dosage forms • hydrodynamically balanced systems • microparticles • microemulsions • solid dispersions • computational intelligence • 3D printing