The research themes of scientific works are focused on developing and evaluating modern forms in the field of pharmaceutical technology, including biopharmaceutical aspects. In light of new research directions, experimental work is being conducted on, among other things, developing new drug forms or their modifications to ensure appropriate quality and safety of use in patients. The main research directions include:
1. technological aspects of improving the pharmaceutical availability of very difficult and practically insoluble medicinal substances,
2. optimization of modern drug forms in the form of: multicompartment systems, tablets and films disintegrating in the oral cavity (ODT, ODF), tablets with a liquid fraction,
3. optimization of drug forms with modified release of medicinal substances based on basic science knowledge,
4. designing drug forms in the aspect of personalized therapy,
5. evaluation of the physicochemical properties of excipients to optimize the technology of manufacturing oral drug forms using modern analytical methods,
6. application of incremental forming tools (3D printing) as a platform for innovative technological solutions.
7. designing research methods to ensure the quality of modern drug forms,
8. decision support systems to optimize the manufacturing strategies of medicinal products based on computational intelligence tools,
9. innovative solutions in drug form design through the use of Quality by Design and Process Analysis Technology principles.
Qualitative studies characteristic of drug forms
In vitro pharmaceutical availability studies
Physicochemical studies of solid and dispersed systems
Modeling release processes using artificial intelligence
Research Equipment
The laboratory and equipment facilities of the Department provide the opportunity to conduct research in a broad range, including technological and analytical work aimed at assessing the quality of drug forms. Among the most important elements of the Department’s equipment are production equipment, which is used for laboratory-scale preparation of various drug forms.
From the perspective of implementing research projects, significant devices available in the unit include impact and rotary tablet presses: Korsch EK0, Korsch PH 103, Erweka TRB 10, allowing for the production of ODT tablets and tablets with pellets, a set for extrusion and spheronization: Alexanderwerk GA 60 extruder, Caleva 120 spheronizer, high-speed FS-GS Fukae Powtec granulator, fluid bed apparatus for granulation, drying, and coating: Bosch-Solidlab and 4M8-F Pro-C-epT, Buchi B-191 spray dryer, Elcometer 4340 device for producing polymer films of precisely defined thickness, Fritsch Pulverisette 7 Classic Line and Premium Line planetary mills, twin-screw melt extruder RES-2P/12A Explorer, Zamak Mercator®, Skawina; equipped with a gravimetric feeder MCPOWDER® Movacolor®, Sneek, the Netherlands, and a cooled transmission belt Zamak Mercator®, Skawina. 3D printers: ZMorph 2.0S, ZMorph VX, Flashforge Adventurer 4.
The Department also has a wide range of research equipment used to assess drug forms, including: sets for testing the release of medicinal substances (apparatus 1 and 2 according to FP): Hanson SR8 water bath and Dissoette II fraction collector and Hanson Research Elite 8 Vision G2, a set for testing the release of medicinal substances by the flow-through method (apparatus 4 according to FP) Erweka DFZ 60 with HKP 60 pump, PharmaTest PTF-E friabilometer, VanKel VK 200 hardness tester, Electrolab ED-2 SAPO disintegration time tester, spectrophotometers: UV-VIS JASCO V-530 and Schimadzu UV-1800 UV-VIS, set for high-performance liquid chromatography HPLC Agilent 1260 Infinity, Malvern Mastersizer 3000 device for particle size measurement by laser diffraction, Schimadzu EZ-SX texture analyzer, Haake VT 550 rheometer, optical microscopes: Hund Wetzlar H600 and MST-ZOOM PZO,
Archival publications:
National Partnerships and Collaboration
International Collaboration and Partnerships